
Portland detective Nick Burkhardt, descended from a long line of warriors known as Grimms, defends his city from magical creatures known as Wesen, which are part human and part animal. Fighting alongside his partner, Hank, colleague Sergeant Wu and friends Monroe and Rosalee, Nick faces off against internal and external forces, including his police captain, Sean Renard.

Nick deals with the consequences of learning the truth about Juliette and Captain Renard; Nick must investigate his own crime; Wu responds to a shooting at Nick's house.

Nick, Monroe and Hank discover that members of the Wesen world have been responsible for a series of bank robberies; Juliette questions her mental state.

When a woman dies after becoming suddenly blind, Nick and Hank discover a Wesen that feeds off tears; Adalind considers her situation; Rosalee tries to help Juliette recover her memory.

The investigation into a gruesome homicide has Nick and Hank battling a Wesen on the Internet; Juliette starts to make sense of her hallucinations.