
Portland detective Nick Burkhardt, descended from a long line of warriors known as Grimms, defends his city from magical creatures known as Wesen, which are part human and part animal. Fighting alongside his partner, Hank, colleague Sergeant Wu and friends Monroe and Rosalee, Nick faces off against internal and external forces, including his police captain, Sean Renard.

The investigation into a double homicide leads Nick to discover a fight club in the Wesen community; Nick must draw on his inner strength to defend Monroe when he gets in trouble while helping out.

A failed jewelry store robbery results in a murder that finds Nick and Hank immersed in a hunt for rare coins; Nick soon learns that these coins have an unsettling effect on whoever possesses them; Captain Renard begin to exhibit unusual behavior.

During an investigation into an arson-related homicide, Nick meets a woman (Danielle Panabaker) in Portland's world of fire-dancing who may be too hot to handle.

After the murder of a familiar shop owner, Nick joins forces with Monroe to help solve the murder; when the shop owner's sister, Rosalee, comes to town, Nick thinks he may have found a new ally in the creature world.