
Portland detective Nick Burkhardt, descended from a long line of warriors known as Grimms, defends his city from magical creatures known as Wesen, which are part human and part animal. Fighting alongside his partner, Hank, colleague Sergeant Wu and friends Monroe and Rosalee, Nick faces off against internal and external forces, including his police captain, Sean Renard.

As Nick delves into the trailer's weapons cabinet and his inner Grimm, the investigation of a dead construction worker leads him into a long-standing conflict in the creature world; the suspect takes it upon himself to summon reapers to town.

Nick and Hank are called to investigate the mysterious death of a wealthy matriarch, after her stepdaughter loses everything in a Ponzi scheme; Juliette does some digging into the mysterious death of Nick's parents in an effort to help find closure.

After Juliette stumbles upon a brutal murder, Nick learns the suspected creature and friend of Monroe is suffering from a mysterious condition, the inability to completely return to human form; this mysterious condition leads them to a therapist.

Nick tries to come to grips with the return of his mother; Monroe intends to awaken Juliette from her mysterious coma; Hank struggles with the shocking truths he has recently learned.