
Portland detective Nick Burkhardt, descended from a long line of warriors known as Grimms, defends his city from magical creatures known as Wesen, which are part human and part animal. Fighting alongside his partner, Hank, colleague Sergeant Wu and friends Monroe and Rosalee, Nick faces off against internal and external forces, including his police captain, Sean Renard.

When homeless people in Portland start to go missing, Nick discovers a black market supplying the Wesen world with human organs.

Nick and Hank find themselves on the hunt for a deadly heartbreaker leaving behind a web of dead bodies; Nick's growing recognition among the creature world is starting to threaten not only his safety but Juliette's as well.

The investigation into a double homicide leads Nick to discover a fight club in the Wesen community; Nick must draw on his inner strength to defend Monroe when he gets in trouble while helping out.

A failed jewelry store robbery results in a murder that finds Nick and Hank immersed in a hunt for rare coins; Nick soon learns that these coins have an unsettling effect on whoever possesses them; Captain Renard begin to exhibit unusual behavior.