
Young war hero Angus "Mac" MacGyver has an extraordinary knack for unconventional problem solving and an extensive bank of scientific knowledge that he believes can best be put to use saving lives, both of which come in handy when he creates a clandestine organization within the United States government to tackle high-risk missions around the world. Working under the sponsorship of the Department of External Affairs, MacGyver quietly prevents disasters with the help of former CIA agent Jack Dalton.

Mac and Jack rush to Mexico to help capture the leader of a drug cartel while the country celebrates Día de Muertos.

Murdoc abducts MacGyver's girlfriend to force Mac to help him rescue his son from a kidnapper; a dangerous person from Murdoc's personal life shows up, giving Mac a glimpse into the villain's past.

Matty sends the team to Ghana to recover a hard drive from an e-waste landfill that is run by a powerful and violent man, leading them to speculate about what could be on the device.

An Irish military intelligence officer claims to know the whereabouts of a lethal bomb maker whom Mac has been hunting for years.