
Young war hero Angus "Mac" MacGyver has an extraordinary knack for unconventional problem solving and an extensive bank of scientific knowledge that he believes can best be put to use saving lives, both of which come in handy when he creates a clandestine organization within the United States government to tackle high-risk missions around the world. Working under the sponsorship of the Department of External Affairs, MacGyver quietly prevents disasters with the help of former CIA agent Jack Dalton.

MacGyver and Riley must find a way to drive a tanker filled with liquid oxygen through a region occupied by rebels and deliver it to a children's hospital; Riley helps MacGyver decide whether to allow his father back into his life.

Mac and Jack rush to Mexico to help capture the leader of a drug cartel while the country celebrates Día de Muertos.

Murdoc abducts MacGyver's girlfriend to force Mac to help him rescue his son from a kidnapper; a dangerous person from Murdoc's personal life shows up, giving Mac a glimpse into the villain's past.

Matty sends the team to Ghana to recover a hard drive from an e-waste landfill that is run by a powerful and violent man, leading them to speculate about what could be on the device.