
Young war hero Angus "Mac" MacGyver has an extraordinary knack for unconventional problem solving and an extensive bank of scientific knowledge that he believes can best be put to use saving lives, both of which come in handy when he creates a clandestine organization within the United States government to tackle high-risk missions around the world. Working under the sponsorship of the Department of External Affairs, MacGyver quietly prevents disasters with the help of former CIA agent Jack Dalton.

MacGyver and Desi help a group of Syrian refugees who are being pursued by human traffickers; Bozer is trapped in Oversight's car, and it's rigged to explode.

Two American tourists go missing while doing a scavenger hunt through some of the world's most dangerous countries; the Phoenix team goes undercover as backpackers to find them and bring them home alive.

When Taylor's former protégé is killed while preventing a bioweapon from falling into the wrong hands, Mac and the team must find the weapon, so Desi can pull off the ultimate heist before it's sold to a terrorist cell.

When Russ is kidnapped, Mac and the team must break out a previously murderous psychopath, now pacifist, from prison to help find him; while on the run, Mac and Desi are forced to confront their relationship issues.