
This long-running animated comedy focuses on the eponymous family in the town of Springfield in an unnamed U.S. state. The head of the Simpson family, Homer, is not a typical family man. A nuclear-plant employee, he does his best to lead his family but often finds that they are leading him. The family includes loving, blue-haired matriarch Marge, troublemaking son Bart, overachieving daughter Lisa and baby Maggie. Other Springfield residents include the family's religious neighbor, Ned Flanders, family physician Dr. Hibbert, Moe the bartender and police chief Clancy Wiggum.

After Bart is turned into an NFT, Marge fights through the blockchain to rescue her son; to track down a gruesome serial killer, Lisa turns to a murderer from her past; an outbreak transforms Springfielders into a plague of lazy, beer-loving oafs.

Homer causes troubles at the nuclear plant; Bart and Lisa X-ray the Halloween candy; the family murders Ned Flanders.

Worried about the effects of violent video games, Marge encourages Bart and Milhouse to play board games; Lisa becomes smitten with a new student, a vampire; while on a second honeymoon, Homer and Marge rescue a castaway who escaped from his ship.

A boulder traps Homer's arm when he takes a drive through a canyon; a spider bite paralyzes Homer; Flanders becomes a vigilante by night; Bart and Milhouse travel to a distant planet to obtain an extract.