After uniting with the Witchblade, an ancient weapon of ecstasy and pain that penetrates the body and mind, Masane's fate was altered. Masane is hunted by the NSWF and is forced to work for the Doji Group, putting her in a battle with her soul.

Masane and her allies prepare for battle; as three twisted Cloneblades move to take the Witchblade by force, thousands of I-Weapons approach to violently complicate matters.

The final battle between the Witchblade and the Cloneblades erupts; consumed with madness, Maria leads her Sisters into a clash with Masane; high atop Tokyo Tower, everyone faces their destiny.

After Shiori's sanity crumbles, she attacks the ship carrying Masane; when the battle ends, the true destiny of those who bear the blade comes into harsh focus.

A new model of X-Con kills in ways that none have before, and with Masane along for the ride, Tozawa becomes a willing participant in the hunt for the monsters.