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In Los Angeles, siblings Ellie (Christina Ricci) and Jimmy (Jesse Eisenberg) come across an accident on Mulholland Drive. As they try to help the woman caught in the wreckage, a ferocious creature attacks them, devouring the woman and scratching the terrified siblings. They slowly discover that the creature was a werewolf and that they have fallen victim to a deadly curse. Now that they have been sliced by the werewolf's claws, they will be transformed into werewolves themselves.
In Los Angeles, siblings Ellie (Christina Ricci) and Jimmy (Jesse Eisenberg) come across an accident on Mulholland Drive. As they try to help the woman caught in the wreckage, a ferocious creature attacks them, devouring the woman and scratching the terrified siblings. They slowly discover that the creature was a werewolf and that they have fallen victim to a deadly curse. Now that they have been sliced by the werewolf's claws, they will be transformed into werewolves themselves.