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New Orleans ad executive Marley Corbett (Kate Hudson) is a free-spirited woman who embraces her easy sexuality, shuns commitment, and gains support and strength from a close circle of friends. Then Marley learns she has terminal colon cancer. Despite her determination not to be tied down in a serious relationship, Marley finds herself falling in love with her handsome doctor (Gael García Bernal), even as her health slowly deteriorates.