
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

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Mark becomes suspicious of a veteran police officer who claims he killed his partner accidentally, when the dead man's widow sues the police department.
Steve and Amanda race to find a stolen antigen for a biological weapon that has infected Mark and Jesse.
The main rival of a celebrated young figure skater becomes the chief suspect in an attack, and Mark is out to prove her innocence.
After a clever serial killer is murdered in jail, Mark and Steve realize an equally lethal copycat is on the loose.