
A Florida team of forensics investigators uses cutting-edge scientific methods and old-fashioned police work to solve crimes. Horatio Caine, a former homicide detective, heads a group of investigators who work crimes amid the steamy tropical surroundings and cultural crossroads of Miami.

The investigators probe what appears to be gang-related gunplay in a hospital emergency room, then discover a cheating girlfriend may be the catalyst for the shooting.

Horatio and the team look for a killer wanted for the murder of a police officer during a traffic stop, but their only lead is an eyewitness report from a suspicious teenage girl.

The murder of a bellboy during tourist season leaves detectives with many suspects, but the luggage he had been loading helps them to uncover a complex counterfeiting operation.

When a woman is swallowed whole by a giant snake, the CSI team suspects that Horatio's nemesis, Clavo Cruz, is behind an operation that uses snakes to smuggle drugs into the country.