
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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Police are able to create a composite sketch of a man burnt beyond recognition. But tracking the killer is more challenging.
By cutting a strand of a murdered man's hair into sections, forensics reveal a record of his last six months alive, and find he was frequently ingesting huge amounts of arsenic.
Teenager is found half-naked with her throat slit; a single foreign hair found on her thumb may finger the killer.
Two women who lived in the same apartment complex were brutally murdered; the similarities of the crime scenes led police to believe they were dealing with a serial killer who hated women, and they had to find him before he struck again.