
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Forensic science and deductive reasoning determine what happened to a mother and daughter while they were on a shopping spree.

When an English couple go missing, police suspect their son killed them and must rely on mud and blood samples found in the couple's two cars to find their bodies.

A mother is determined to discover what happened when her daughter is injured in a hit-and-run accident.

When a woman goes missing from her home, police focus on her husband when an airline luggage tag and luminol point to an affair and murder; footage from a TV crew and Coast Guard photographs lead investigators to the suspect's missing boat.