
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A serial killer in Tampa, Fla., taunts police by strangling prostitutes and leaving their bodies in plain sight, but tire marks and fibers lead to the culprit.
Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.
A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.
When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.