
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

For ten years, the disappearance of a college co-ed remained a mystery; new scientific testing cast a different light on a man who had been a suspect all along.

New evidence including fibers and weather patterns point to a different killer in the 1986 case of a Pennsylvania dentist's murdered wife.

Tipster is found dead after revealing that a woman's death 16 years ago was murder.

When a young woman goes missing on the way to the train station, investigators use a strand of hair and a bloody pillowcase to find a suspect.