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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S4, EP10 "The Alien Parasite Hypothesis"
Amy realizes she has feelings for Penny's ex; Koothrappali and Wolowitz try to prove who would be a better superhero.
S4, EP11 "The Justice League Recombination"
The guys try to bond with Penny's new boyfriend through a costume contest.
S4, EP12 "The Bus Pants Utilization"
Leonard's idea for a smartphone application causes friction in his friendship with Sheldon.
S5, EP5 "The Russian Rocket Reaction"
Wil Wheaton invites Leonard and Sheldon to a party at his house; Howard receives an opportunity.
S12, EP24 "The Stockholm Syndrome"
Bernadette and Wolowitz leave their kids for the first time; Penny and Leonard try to keep a secret; Sheldon and Amy stick together; Koothrappali makes a new friend; the gang travels together into an uncharted future.
S12, EP23 "The Change Constant"
Sheldon and Amy await big news.