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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S6, EP22 "The Proton Resurgence"
Leonard and Sheldon hire the host (Bob Newhart) of their favorite childhood TV show to perform; Bernadette and Howard run into trouble while dog-sitting for Raj's pet.
S3, EP11 "The Maternal Congruence"
Leonard is horrified when his mother (Christine Baranski) visits.
S11, EP23 "The Sibling Realignment"
Sheldon's mother won't attend his wedding unless he invites his brother; the Wolowitz kids inadvertently infest Amy, Bernadette, Wolowitz and Koothrappali with pink eye.
S11, EP24 "The Bow Tie Asymmetry"
When Amy's parents and Sheldon's family arrive, everybody is focused on making sure the wedding arrangements go according to plan -- everyone except the bride and groom.
S12, EP20 "The Decision Reverberation"
Koothrappali is worried people won't take him seriously in his own field after publishing a paper that suggests he may have discovered alien life; Leonard wants to be the principal investigator on a plasma physics study.
S12, EP19 "The Inspiration Deprivation"
The weight of winning a Nobel Prize weighs heavy on Amy's shoulders; Koothrappali and Wolowitz try to relive the good old days after Wolowitz buys a scooter that looks like the one he had years ago.
S12, EP18 "The Laureate Accumulation"
When competitors Pemberton and Campbell charm America on a publicity tour, Sheldon and Amy try to win over Nobel laureates Kip Thorne, George Smoot and Frances Arnold; Halley's fear of the dark leads to opportunity and conflict.
S12, EP17 "The Conference Valuation"
When Penny and Bernadette go to San Diego for a pharmaceutical sales convention, Wolowitz is left in charge of the kids; Sheldon finds a book about experimenting on kids.
