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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S4, EP5 "The Desperation Emanation"
Leonard realizes he is the only one in his group without a girlfriend; Sheldon wants to get rid of his girlfriend.
S4, EP6 "The Irish Pub Formulation"
Leonard keeps an affair a secret from Sheldon, Howard and Raj.
S4, EP7 "The Apology Insufficiency"
Sheldon's interview with the FBI jeopardizes Wolowitz's security clearance.
S4, EP8 "The 21-Second Excitation"
While the guys camp out for a long-awaited movie screening, Penny and Bernadette invite Amy to her first slumber party.
S12, EP24 "The Stockholm Syndrome"
Bernadette and Wolowitz leave their kids for the first time; Penny and Leonard try to keep a secret; Sheldon and Amy stick together; Koothrappali makes a new friend; the gang travels together into an uncharted future.
S12, EP23 "The Change Constant"
Sheldon and Amy await big news.
