
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
Unhappy to learn that Penny is seeing someone, Leonard summons the courage to ask another woman on a date.
Getting fired gives Sheldon the opportunity to explore life beyond physics, but when he spends his time weaving ponchos and acting like a shut-in, Leonard calls Sheldon's mother for assistance.
Leonard, realizing his pursuit of Penny is fruitless, has an unexpected encounter with a fellow scientist (Sara Gilbert).
Leonard, Sheldon, Wolowitz and Koothrappali attend Penny's Halloween party.