
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.

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A powerful divorce lawyer with a lot of enemies is murdered; the three-month separation between Booth and Brennan starts to take its toll.
After an explosion in a hotel garage, the Jeffersonian team tries to identify victims by investigating remains found at the scene; Sweets works with a temporary partner (Danielle Panabaker) while Booth works on the department's budget.
While investigating the death of an animal expo employee, the team is drawn into the world of animal trafficking; Brennan thinks she would be a good presidential candidate; Sweets and Daisy make a change.
The team investigates the death of a woman whose body was found in the trash; Booth invites Sweets to stay with him and Brennan until he finds a new place.