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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

A free-spirited beauty moves in next door to two physicists.

The Big Bang Theory

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Four single friends -- comic Jerry Seinfeld, bungling George Costanza, frustrated working gal Elaine Benes and eccentric neighbor Cosmo Kramer -- deal with the absurdities of everyday life in New York City.

Friends living in Manhattan obsess over little things.

Seinfeld

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This animated series features the adventures of the Griffin family. Endearingly ignorant Peter and his stay-at-home wife, Lois, reside in Quahog, R.I., and have three kids. Meg, the eldest child, is a social outcast, and teenage Chris is awkward and clueless when it comes to the opposite sex. The youngest, Stewie, is a genius baby who is bent on killing his mother and destroying the world. Brian, the talking dog, keeps Stewie in check while sipping martinis and sorting through his own issues.

The adventures of an eccentric family living in New England.

Family Guy

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This U.S. adaptation -- set at a paper company based in Scranton, Pa. -- has a similar documentary style to that of the Ricky Gervais-led British original. It features the Dunder-Mifflin staff, which includes characters based on roles in the British show -- and, quite possibly, people with whom you work in your office. There's Jim, the likable employee who's a bit of an every man. Jim has a thing for receptionist-turned-sales-rep Pam -- because office romances are always a good idea! There's also Dwight, the co-worker who is successful but devoid of social skills and common sense.

Workers plod along at Dunder Mifflin's paper-supply company.

The Office

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Mike's dying landlord offers to sell him the apartment building.

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